Endocrine Abstracts

The National Paediatric Diabetes Audit 2021 uncovered widening disparity in the utilisation of diabetes technologies among children and young people (CYP) with type 1 diabetes from ethnic minorities and low socioeconomic groups. Our data revealed that only 27.5% of CYP from ethnic minorities were using insulin pump therapy, compared to 50% from a white background. Unfortunately, our current staffing levels and available resources were inadequate to address this issue effective...

Background: Hyperthyroidism often presents with aberrant liver function. The differential diagnosis of this presentation includes thyrotoxicosis-associated liver dysfunction or antithyroid drug-induced liver dysfunction. We present a case where Propylthiouracil treatment resulted in acute liver failure.Case Presentation: A female patient diagnosed with Grave’s disease in August 2023 initially received carbimazole but discontinued this due to vomitin...

Gallium68-Dotatate PET-CT is a somatostatin-receptor (SSTR) based imaging modality employed in the diagnosis and follow-up of Neuroendocrine Tumours (NET). We set out to investigate the incidence of incidental findings, some of which are related to SSTR expression, in our NET patient cohort in Oxford University Hospital. Sixty-eight patients underwent Gallium68-Dotatate PET-CT between June 2020 and June 2021. 40 patients (59%) were female, and median age ...

Background: It is apparent that COVID-19 may cause persistent symptoms beyond 12 weeks (‘long COVID’). However its underlying pathophysiology is unclear. Several symptoms of long COVID draw similarities to that of endocrine diagnoses. We recently observed that adrenal and thyroid function were normal in survivors of COVID-19 at follow-up. Here we assess additional endocrine axes that could plausibly have a role in long COVID to determine their relationship to ongoing...

Background: One of the main indications for parathyroidectomy surgery in primary hyperparathyroidism (PHPT) is osteoporosis. NICE guideline recommends 2-3 yearly Dual-energy X-ray absorptiometry (DEXA) assessments to evaluate bone mineral density (BMD) in asymptomatic PHPT. Objective: We undertook an audit to evaluate bone health practice in PHPT patients in line with NICE guidelines.Methodology: Retrospective case notes and electr...

Background: Advanced neuroendocrine tumors (NETs) are associated with poor prognoses. A 4-dose regimen of lutetium Lu 177 (177Lu)-DOTATATE has been shown to improve progression-free survival (PFS) and overall survival (OS) in patients with advanced NETs. This is the first United States (US) study to evaluate the effectiveness and safety of additional doses in patients with progressive NETs.Methods: This was a retrospective chart review of 31 a...

Background: Appendiceal GCA is a tumor which has been misunderstood for decades. GCAs are comprised of goblet-like mucinous cells, with variable numbers of neuroendocrine and Paneth-like cells and lie on the spectrum between appendiceal adenocarcinoma and neuroendocrine tumors. Prognosis depends on the stage and tumor grade; 30% of patients with low-grade and 50-70% of high grade GCAs present with metastatic disease. Currently, there are limited systemic therapy options and de...

Introduction: Gestational trophoblastic disease (GTD) is a group of disorders arising from abnormal proliferation of placental trophoblasts. Hydatiform mole (molar pregnancy) is a premalignant condition which is further devided in to partial and complete mole. Incidence of molar pregnancy is estimated to be 1 in 1000 pregnancies. Hyperthyroidism is one of the rare complications of molar pregnancy which, if not detected and treated, can lead to adverse consequences. We describe...

Introduction: Adrenocortical Carcinoma (ACC) is a rare endocrine neoplasm with poor prognosis, and an estimated incidence of approximately 2.5/1,000,000 patients. The functional state of these tumors varies from non-secretory (20%) to non-secretory. The latter category is subdivided into glucocorticoid-producing (45%) or glucocorticoid-androgen producing (45%) or androgen-producing only (10%). We report a case of a 35-year-old lady who initially presented with symptoms of Cush...

Introduction: Cushing’s syndrome is a rare endocrine disorder characterized by excess cortisol secretion. It can be caused by various etiologies, including ACTH-dependent and ACTH-independent forms. We report a case of a 78-year-old male who presented with severe hypertension, refractory hypokalemia, and severe hypercortisolaemia, diagnosed with ACTH-dependent Cushing’s syndrome with bilateral adrenal hyperplasia.Case Presentation: A 78-year-ol...